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Zarqa’s Cancer Panel

About Cancer

Welcome to Zarqa Genomics Lab (ZGL), your trusted ally in unravelling the mysteries encoded within your patients’ DNA. As a premier genomics laboratory, we specialize in the sequencing and interpretation of genomic data to provide unprecedented medical insights.

Our Services

Whole genome sequencing (WGS)

Stands as an advanced genetic analysis technique gaining recognition as the preferred first-line genetic test in routine clinical settings. It transcends the limitations of targeted tests by encompassing coding and non-coding regions, along with mitochondrial DNA (mtDNA), thus offering a holistic view of your patients’ genetic landscape and optimizing diagnostic value.

Whole exome sequencing (WES)

Presents a comprehensive approach, meticulously sequencing the exons of all protein-coding genes alongside thousands of known disease-causing variants. Despite representing only 1-2% of the human genome, the exome harbours approximately 85% of known disease-related variants.

Features

  • Transform Patient Management: Diagnostic findings can yield tangible changes in patient management.
  • Shorten Diagnostic Journey: It holds significant potential in curtailing the diagnostic odyssey for neonates and paediatric patients with suspected genetic diseases.
  • Cost-Effective Solution: as a primary diagnostic tool, offers cost-effective solutions for patients suspected of rare diseases compared to alternative genetic tests.

Who Can Benefit?

  • Individuals with a familial predisposition to cancer, seeking proactive genetic testing for risk assessment and early intervention.
  • Patients diagnosed with cancer at a young age, where hereditary factors are suspected.
  • Individuals presenting with multiple primary cancers, suggesting an underlying genetic predisposition.
  • Those diagnosed with rare cancer types, where genetic testing can provide critical insights into disease etiology.
  • Individuals exhibiting symptoms or clinical features consistent with known cancer syndromes.
  • Individuals identified as carriers of cancer-related genetic mutations seeking further evaluation and management.

Unveiling the Genetic Basis:
A Molecular Atlas of Cancer Disorders

Breast Cancer

NGS analyses genes such as BRCA1 and BRCA2, shedding light on hereditary breast cancer susceptibility.

Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer - HNPCC)

Identification of mutations in genes like MLH1, MSH2, and MSH6 provides insights into Lynch syndrome.

Familial Adenomatous Polyposis (FAP)

Mutations in the APC gene are scrutinized to understand the genetic basis of FAP.

Hereditary Diffuse Gastric Cancer (HDGC)

NGS examines mutations in the CDH1 gene, which are linked to HDGC.

Li-Fraumeni Syndrome

TP53 gene mutations are key markers analyzed through NGS to diagnose this syndrome.

Retinoblastoma

RB1 gene mutations are explored to unravel the genetic foundation of retinoblastoma.

Multiple Endocrine Neoplasia (MEN)

Genetic variations in MEN1 and RET genes are thoroughly investigated for their roles in MEN types 1 and 2.

Hereditary Breast and Ovarian Cancer Syndrome (HBOC)

Besides BRCA1 and BRCA2, other genes like PALB2, CHEK2, and ATM are analyzed for their roles in HBOC.

Neurofibromatosis Type 2 (NF2)

NGS examines NF2 gene mutations to elucidate the genetic basis of this disorder.

Tuberous Sclerosis Complex (TSC)

Genetic investigations focus on TSC1 and TSC2 genes, which are implicated in TSC.

Medullary Thyroid Cancer (MTC)

RET gene mutations are key genetic markers examined for MTC.

Additional Services

Non-Invasive Prenatal Testing (NIPT), Genetic Carrier Screening, BRACA1/ BRACA2 Gene Panel, Paternity Testing, Sanger Sequencing Validation, Genetic Counseling, services of clinical scientist for choosing test, analyses on raw data, reanalyses on analysed report for deeper insights.

Sample types: saliva, blood, DBS cards, isolated DNA

TAT: All samples are processed within 45 working days

Zarqa Genomics is committed to empowering healthcare professionals like you with invaluable genetic insights to enhance patient care and improve health outcomes. Partner with us on the journey to personalized medicine and transformative healthcare solutions.